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Studies indicate that aminoglycoside ototoxicity may also be mediated by genetic mutations in mRNA, which increase susceptibility to aminoglycoside-induced oxidative stress (Fu et al

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By blocking presynaptic inhibitory autoreceptors, these drugs prevent negative feedback and increase the release of norepinephrine and serotonin

Phytomedicine 135:156064 Weaver RJ, Blomme EA, Chadwick AE, Copple IM, Gerets HHJ, Goldring CE, Guillouzo A et al (2020) Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models